Background: H.pylori is a gram-negative bacterium found on the luminal surface of the gastricrnepithelium. At least 50% of the world's human population has H.pylori infection. Studies havernshown an increased prevalence of this bacteria in people infected with HIV relied on the CD4rncount level.rnAim:To determine the burden H.pylori and its association with CD4 count among HIV infectedrnindividuals who attend the ART service in Kotebe Health Center, Yeka Sub City, Addis Ababa,rnEthiopia.rnMethods:A cross sectional Study was conducted from October to November 2016 on 388HIVrninfected individuals at Kotebe Heath Center, Yeka Sub City Addis Ababa. Convenientrnsampling technique was employed to include study participants who met the inclusion criteria.rnCD4 count and hemoglobin level with demographic and other variables such as habit ofrndrinking alcohol, habit of eating chat, habit of personal hygienic practice, and also direct stoolrnmicroscopy examination was included in the study.rnResults:The prevalence of H.pylori infection among study subject was 54.8%, H.pylorirninfection among female participant was 51.8% (133/256) and among male participant wasrn60.6% (87/143) with X2 = 2.745a and P-Value 0.098. The prevalence of H.pylori infection inrnpatient with CD4 count level less than 500 was 54.4% (131/141) and with CD4 count levelrngreater than 500 was 55.1% (81/147).The prevalence of H.pylori was 67.1% (61/91) amongrnHIV clients with people in the house hold greater than four. The prevalence of H.pylorirninfection among HIV clients those use tanker water, wheel water, pipe water was 50% (2/4),rn25% (4/16) and 55.9% (226/401) respectively (X2= 6.114a P. value=0.047).rnConclusion: There was no significant association between the prevalence of H.pylori and levelrnof CD4 cell count. But there was significant association between number people in the housernhold and type of water used for drinking. And there was no significant association betweenrnwith socio demographic data like age, sex, marital status, educational level, stage of ARTrntaking, habit for drinking of alcohol, smoking, eating of chat, and habit of hand washing, andrnpervious history of GIT. The health facility and other responsible body must be conscious inrncreating awareness on the possible transmission of the disease.rnKey words: H.pylori stool antigen test, CD4 cells, HIV, ART