Background:rnLymph node comprises an important part of defense system in the human body as it trapsrnor filters foreign particles. Lymphadenopathy refers to lymph nodes with abnormal size,rnnumber or consistency (1). The cause of lymphadenopathy is varied and may berninflammatory or neoplastic process. There is a wide variation in pattern of disease inrndifferent age groups, gender and in various countries. The main aim of FNAC is for rapidrndiagnosis of lymphadenopathy with simple, accurate procedure and with minimumrntrauma and low cost. It identifies lymph node enlargements with malignant potential thatrnrequires treatment and those benign conditions that can be observed clinically.rnMethods and Materials: Retrospective cross-sectional descriptive study was conductedrnon 771 lymphadenopathies cases in which FNAC was performed in patients referred tornpathology laboratory of black lion hospital in the three years period (from January 01,rn2018 to August 30, 2020).rnResults: Of the 771 lymph node FNAC biopsy specimens received, 409 (53%) werernfemales and 362 (47%) were from males making F: M ratio of 1.13:1. with mean, lowestrnand highest age limits of 33.6 years, 3 month and 84 years respectively. Most of thernpatients were in the age range of 21-30 years accounting for 152(19.7%). Localizedrnlymphadenopathy was observed in 638 (82.7%)cases. Cervical lymphadenopathyrnpredominated, comprising 211 (27.4%)cases. Metastatic disease and reactivernlymphadenitis were the major causes of lymphadenopathies constituting 256 (33.2%) andrn176(22.83%) respectively. Metastatic tumor was commonest in adult females above 30rnyears and reactive lymphadenitis was the predominant cause of lymph node enlargementrnin age groups (0-30 years ) and rare above the age of 40 years. 166 (21.5%)lymphomarncases were seen out of these 132 (79.5%) of the cases were Non-Hodgkinâ€™s lymphoma ofrnthese 67.4% occurred in males and 32.6% in females followed by Hodgkinâ€™s lymphomarnaccounting 27(16.3%) and 63% cases were seen in males and 37% cases in females. 7rn(4.2%) cases diagnosed as lymphoma only. Other benign lesions identified were;rntuberculosis lymphadenitis constituting 83 (10.8%). Suppurative lymphadenitis 10 (1.3%)and other benign diseases 2(0.3%)were seen. Other malignant lesion identified in thisrnstudy were non-specified malignant tumor, leukemic infiltration, myeloid sarcoma andrnplasmacytoma accounting 11 (2.5%), 4(0.9%), 2(0.5%) and 1(0.2%) respectively.rnConclusion: In this study the majority of patients with lymphadenopathy had metastaticrndeposits commonly ductal carcinoma. Reactive lymphadenitis was the second mostrncommon pathology Followed by lymphoma.