Synthesis And Antimicrobial Testing Of Triphenyltinsalicylatepyridine

Synthetic, spectroscopic and biological studies of triphenyltinsalicylate pyridinern(TPhTSaPy) complex derived from pyridine having a nitrogen donor system havernbeen undertaken. Silversalicylate, on interaction with triphenyltin chloride (TPhTCl),rnyielded triphenyltinsalicylate (TPhTSa), which upon further interaction of thernintermediate (TPhTSa) with pyridine afforded the TPhTSaPy complex having arnSn N bond. The structures of these compounds were elucidated by elementalrnanalysis and spectroscopic (IR, Mass, 1H and 13C NMR) studies.rnThe growth-inhibiting potential of the final product (TPhTSaPy) and its intermediatern(TPhTSa) was compared with that of the commercially available antifungal drugrnTPhTCl against a series of medically important pathogens including fungal, andrnGram-positive and Gram-negative bacterial strains.rnThe results revealed that TPhTSaPy was strongly active against Staphylococcusrnaureus 29737, S. aureus ML 267, Escherichia coli RP4, Pseudomonas aeruginosarnATCC 25619 and Vibrio cholerae 2 while it failed to exhibit any activity againstrnSarcina luteus 9341, Bacillus subtilis ATCC 6633 and B. pumilus 8241 at the testedrnconcentrations. TPhTSaPy displayed moderate activity against E. coli K88, E. colirnATCC 10536, E. coli VC Sonawave 3:37 C, E. coli 18/9, E. coli CD/99/1, Shigellarndysentery 1, S. dysentery 8, S. soneii 1, S. soneii BCH 397, S. boydii 937 and S.rnflexneri Type 6, V. cholerae 1037 and V. cholerae 785. The lowest MIC (25 μg/ml)rnvalue was observed against S. aureus 29737, S. aureus ML 267, E. coli RP4, P.rnaeruginosa ATCC 25619 and V. cholerae 2. TPhTCl was active against E. coli andrnV. cholerae 2. But, S. luteus 9341, B. pumilus 8241 and B. subtilis ATCC 6633rnstrains were completely resistant to it. On the other strains of bacteria it showedrnmoderate activity. The lowest MIC (25 μg/ml) value was observed against E. colirnCD/99/1, E. coli 18/9, E. coli K88 and V. cholerae 2.rnAccording to these results, TPhTSaPy was more active than TPhTCl against S.rnaureus, and P. aeruginosa but less active against E. coli. Thus, TPhTSaPy has shownrna broad antibacterial spectrum than TPhTCl. But, the activity of TPhTCl against thernfungal strains tested in the present study namely, Candida albicans ATCC 10231,rnAspergillus niger ATCC 6275, Penicillium notatum ATCC 11625 and P.rnfuniculosum NCTC 287 was superior to that of TPhTSaPy.

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