In Vivo Antimalarial Activity Of The Hydroalcoholic Extract Of Rhizomes Of Kniphofia Foliosa Hochst And Kniphofia Insignis Rendle And Their Constituents

Malaria is a major public health problem that affects millions of people. The widespread rnemergence of antimalarial drug-resistant Plasmodium strains especially the recent emergence of rnartemisinin resistance poses a great challenge in future prevention and control of malaria. As a rnresult, there is an urgent need to discover new, safe, and effective antimalarial drugs with novel rnmechanisms of action. In this regard, traditional medicinal plants have paramount importance as rnseen in the discovery of the forefront antimalarials. Kniphofia foliosa Hochst and Kniphofia rninsignis Rendle are endemic Ethiopian plants traditionally used to treat malaria in different parts rnof the country. In the present study the 80% methanol rhizome extracts of both plants and some rnof their constituents were investigated for their antimalarial activity. rnFractionation of the hydroalcoholic extract of K. foliosa followed by preparative thin layer rnchromatography (PTLC) led to the isolation knipholone, dianellin, 10-knipholone gentibioside rnand 12-hydroxypentadec-9-en-1-yl methyl phthalate (HPMP) identified on the basis of rnspectroscopic (ESI-MS, 1D and 2D-NMR) data. Similarly, knipholone was isolated for the first rntime from crude phenolic fraction of K. insignis. The hydroalcoholic extracts of both plants, the rnphenolic fractions from K. foliosa and the compounds isolated thereof showed in rnvivo antiplasmodial activity (p

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