Malaria is a major public health problem in the world in general and developing world inrnparticular. It is known to cause 1-2 million deaths per year, with an annual incidence of 300-rn500 million clinically manifested cases and with more than 2 billion people at risk ofrninfection. It is becoming more difficult to prevent and to treat malaria due to the increasingrnresistance of the transmitting mosquito and of the malaria parasite to the insecticides andrndrugs that have been commonly used. The importance of malaria as a major public health andrndevelopment problem has been reviewed on a number of occasions in Ethiopia. This studyrnaims at investigating the in vivo antiplasmodial activity of the known traditionally used herbalrndrugs. A rodent malaria parasite, Plasmodium berghei, maintained in EHNRI laboratory, wasrninoculated into young male albino mice. Male mice were infected with 1x107 parasitesrnintraperitonially. The extracts were administered by intra gastric tube daily for fourrnconsecutive days starting from the day of parasite inoculation. Control groups received thernsame amount of solvent (vehicle) used to suspend each dose of the herbal drug andrnChloroquine was used as a standard drug given by the same route. The results showed thatrnAsparagus africanus Lam. (Liliaceae) root and areal part and Withania somnifera (L) Dunalrn(Solanaceae) leaf and root bark are effective in P.bergei malaria, which is inconformity to thernclaim that they have therapeutic values in human malaria in traditional medicine. This studyrncould partly confirm the claim, facilitate in initiating further in-depth investigation usingrndifferent experient model.rnviirnKey words: Asparagus africana Lam., Withania somnifera (L) Dunal, Plasomodium berghei,rnacute toxicity, in vivo, antimalarial activity,