An ethnobotanical study of traditional medicinal plants used by indigenous people in WonagornWoreda, SNNPR was carried out from November 1, 2006 to December 3, 2006. A total of 80rninformants (60 males and 20 females) between the ages of 20 and 85 were randomly selectedrnfrom the study sites or kebeles. Out of these, 30 key informants (22 males and 8 females) werernsystematically selected based on recommendation from elders and local authorities.rnEthnobotanical data were collected using semi-structured interviews, field observations, andrngroup discussions. Informant consensus, preference ranking, direct matrix ranking, pairedrncomparison and informant consensus factor (IFC) were calculated. A total of 198 plantrnspecies: 133 species from wild vegetation, 43 species from home gardens and 22 species fromrnboth, belonging to 174 genera and 76 families were collected in the study area. Of these, 58rnmedicinal plant species belonging to 39 families and 55 genera were useful for treatment ofrnhuman health problems. Twenty-seven species (46.5%) of the medicinal plants were shrubs,rnfollowed by 19 (32.7%) herbs, and 12 (20.6%) trees. The most frequently used plant partsrnwere the roots (17, 29.3%), followed by leaves (14, 24.1%). Different preparation methodsrnwere reported. However, the most widely used method of preparation was in the form ofrnpowder (32, 36.4%), and 29 (32.9%) of the preparations were made by crushing andrnpounding and mixed with different plant parts or different part of the same plant. Therncommon route of application recorded was internal, particularly oral (37, 63.7%). Pairedrncomparison and preference ranking showed that people have preferences for some speciesrnover others in treating the same ailment. The medicinal plants that are preseumed to berneffective in treating certain diseases such as, â€˜malaria and headacheâ€™ (82.3%) had higher ICFrnvalue. Agricultural expansion, firewood collection, grazing and drought are major threats tornmedicinal plants. It was found that, there is little practice of bringing medicinal plants underrncultivation. Indigenous practicies, various cultural and seasonal restrictions of collectingrnmedicinal plants have contributed to the management and conservation of medicinal plants inrnthe area. It is therefore, recommended that people need to be encouraged to cultivaternmedicinal plants in their home garden. The participation of the local people and awarenessrncreation through training or education on sustainable utilization and management of plantrnresources should be encouraged.