An ethnobotanical study was conducted in Wondo Genet Wereda between December 01 to 23, 2010 andrnFebruary 02 to 21, 2011. The objective of this study was to document indigenous medicinal plantrnutilization, management and the threats affecting them. Information was gathered from 80 people (63rnmales and 17 females). The informants, except the healers, were selected randomly and no appointmentrnwas made prior to the visits. Ethnobotanical data were collected using semi-structured interviews withrninformants, field observations, guided field walk, group discussion, preference, paired comparison andrndirect matrix ranking with traditional medicine practitioners. The ethnomedicinal use of 85 plant speciesrnwas documented in the study area used as cure for 61 ailments. They are distributed across 79 generarnand 44 families. Of these, 54 medicinal plants were reported for human ailments treatment, eight forrnlivestock and 23 for both human and livestock ailment treatment. Most of the medicinal species wererncollected from the wild. The most frequently utilized plant parts were leaves followed by stem bark andrnroots. The largest number of remedies was used to treat intestinal parasites infections followed byrnpneumonia and external injuries like body swellings. This probably indicates a high incidence of theserntypes of diseases in the area, possibly due to the poor socio-economic and sanitary conditions of thernpeople. The administration routes are oral, external, ear and nasal. Preference ranking analysis indicatesrnthat Solanum incanum ranked first and most effective medicinal plant to cure intestinal problemsrnfollowed by Phytolacca dodecandra and Vernonia amygdalina in human and for livestock Ranunculusrnmultifidus ranked first and most effective medicinal plant to cure pneumonia. The pair wise comparisonrnshowed that Stephania abyssinica ranked first and most effective medicinal plant to cure jaundice inrnhumans as compared to the others. Direct matrix analysis showed that Eucalyptus citriodora ranked firstrnand it is the most preferred plant by local people for various uses. Cordia africana and Podocarpusrnfalcatus scored second and third. This shows that both trees are more preferable or have high utilityrnvalue for the local community. The medicinal plants that were presumed to be effective in treating arncertain disease had higher ICF values. Informant consensus analysis showed that ailments like rabies,rnpoisoning and snake bite scored the highest value (0.98). Evil spirit and evil eye scored the secondrnhighest value (0.97). Wound and body swelling (0.83), intestinal parasite (0.75) and pneumonia andrnjaundice scored the lowest values (0.63) respectively. The principal threatening factors for medicinalrnplants reported were agricultural expansion and fire. Documenting the eroding plants and associatedrnindigenous knowledge can be used as a basis for developing management plans for conservation andrnsustainable use of medicinal plants in the area.rnKey words: Wondo Genet, Medicinal plant, Indigenous knowledge, Informant consensus