Across-sectional study was conducted on a totel of 355 dairy cattle and 8 pulmonary tuberculosis patients between October 2007 and April 2008 to determine the prevalence, risk factors and public health implication of bovine tuberculosis (BTB) in Alage. Single intradermal Comparative tuberculin (SIDCT) test, bacterial isolation and polymerase chain reaction (PCR) based typing were performed on both sputum samples of pulmonary tuberculosis patients and milk of reactor cows.