In Vivo And In Vitro Antifertility Properties Of Vernonia Amygdalina Del

Rapid population growth is becoming a problem which causes sever pressure on economic,rnsocial and cultural resources. Control of fertility using traditional antifertility plants hasrnbeen practiced for many years in Africa including Ethiopia. Vernonia amygdalina locallyrnknown as “Girawa” is one of the many plants used for fertility regulation in Ethiopia. Inrnthe present study the anti-implantation and abortifacient property of 95% ethanol crudernextract of the leaves of the plant in vivo and the spasmogenic effect of its fractions inrnisolated mouse uterus (MU) in vitro were tested. The crude extract of the plant wasrnevaluated for its anti-implantation effect a doses of 0.385, 0.5 and 1.0 g/kg body weight inrnmice. Its abortifacient property was also studied at doses of 1, 2 and 3 g/kg body weight.rnThe crude extract was further fractionated to F1, F2, F3 and F4 to see the possiblernuterotonic property in the presence of an agonist ACh as a control. The crude extractrncaused a significant (p

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