Background: Diabetes self-care practice is essential to prevent and control complications ofrndiabetes mellitus. There are some studies conducted regarding diabetes self-care in Ethiopiarnbut there is no one in type 2 diabetes adults who have comorbid peripheral neuropathy. rnObjectives: The aim of this study was to assess self-care practice intype2 diabetes adults withrnand without comorbid neuropathy in Addis Ababa rnMethods: An institution based cross-sectional study was conducted at three governmentalrnhospitals: Tikur Anbessa Specialized Hospital, St. Paul Hospital, and Zewditu MemorialrnHospital. Sample size was 216 type 2 diabetes adults (108 with peripheral neuropathy 108rnwithout it). Sociodemographic variables, neurologic states, personal and self-care practicernparameters were checked during data collection. Data coding and cleaning was done before thernanalysis of the data. Linear regression analysis was used to assess the association betweenrndependent and independent variables. rnResult: A total of 216 study participants were included in the study with the response rate ofrn99.1% and from this 111(55.4%) were female. In this study, type 2 DM without peripheralrnneuropathy had better diet, exercise, foot care, and SMBGL practice with significant meanrndifference (p-value < 0.01)).Dietary self-care practice decreases by 0.022 units for every 1rnmg/dl increase in FBS while dietary self-care practice increases by 0.228 units for every 1 unitrnincrease in social support score in type 2 DM patients without peripheral neuropathy.rnHousewife (P-vale = 0.013) and others occupational group (P = 0.030) were significantlyrnassociated with exercise self-care practice among type 2 diabetes patients without peripheralrnneuropathy. Being male was significantly associated with foot self-care practice amongrnpatients without peripheral neuropathy (P-value = 0.019). Being student by occupation (Pvaluern=rn0.016)rnandrnhavingrnglucometryrnatrnhomern(P-valuern=rn0.003)rnwerernsignificantlyrnassociatedrnrnwithrnSMBGLrnpracticernamongrnpatientsrnwithoutrnperipheralrnneuropathy.rnCONCLUSION: Type 2 DM patients without peripheral neuropathy have good diet, exercise,rnfoot care, and SMBGL practice than with peripheral neuropathy.