The study was conducted in four districts of Gurage zone, Sothern Nations Nationalities and Peopleâ€™s Region to identify the major constraints of dairy cattle production, to determine the quantity and quality of available feed resources, to determine the livestock feed balance, to identify the interdependence between that exists between cattle and enset and to assess the role of cattle in enset based agriculture in relation to food security status of farming families. Households of 360 were selected using proportional sample size determination (Cochran, 1909; Thrustfield, 2013) and individually interviewed with personal observation and focus group discussion. The overall average family size of 7.71Â±.18 persons, herd size of 4.87Â±0.12 heads of cattle (3.35 TLU) and land holding of 1.75Â±0.05 hectare per household were obtained in this study. Around 88.05% of the farmers in the study areas were keeping cattle primarily for the production of milk and manure while 11.95% held cattle mainly for milk production and traction. Mating systems used by households predominately (83.6%) covered by the natural mating. Some (15.3%) of households reported to use AI and natural mating. About 95.55% of cattle were local breed. The overall average lactation yield of indigenous dairy cows was 1.53kg with lactation length of 7.23 months. The overall average age at first service and age at first calving for local heifers, respectively, was 53.44 and 62.44 months. The overall average days open of 211.44 and calving interval of 481.44 days was reported for local dairy cows. Farmers of 82.78% were relied on river water source for their cattle. Extensive-dairying is the dominant system where farmers majorly depend on enset leaf and leaf midribs (51.05% DM) to feed their cattle. Feeding systems of Grazing & cut and carry; Tethering, grazing and cut & carry as well as Tethering & cut and carry were practiced by farmers of 34.7%, 31.4% and 33.9%, respectively. Households of 77.5% gave feeding priority to the lactating cows and calves. The prevalent diseases of the study areas include: Anthrax, Blackleg, FMD, Bovine Pasteurollosis, LSD, Mastitis, Pneumonia, Metritis and parasites and their infestation depends majorly on seasons of the year. The DM produced from leaf and leaf midribs of enset, crop residues and natural grasses in tons, respectively, were 506.4; 312.33 and 141.62 in dega whereas it was 662.96; 472.83 and 207.33 in weinadega. The DCP produced from enset leaf and leaf midribs, crop residues and natural pasture, respectively, were 51,819.91 kg; 8,401.16 kg and 10,335.43 kg in dega while it was 55,217.94 kg; 13,799.32 kg and 11,490.23 kg in weinadega. The ME produced in dega was 4,420,872; 2,296,269.8 and 1,188,191.8 MJ whereas it was 6,013,047.2; 3,430,459.7 and 1,689,739.5 MJ in weinadega from enset parts, crop residues and natural pasture, respectively. The amount of DM, DCP and ME produced by individual household per year in weinadega agroecology were significantly higher (p