The study was conducted from September 2018 to June 2019 in Veterinary Teaching Hospital foundrnin the College of Veterinary Medicine and Agriculture of Addis Ababa University, and Dirernveterinary clinic, with objectives of conducting various surgical treatments in different domesticrnspecies of animals with determining postoperative complications and surgical outcomes of eachrncase. The study was based on the case study of the presented cases. The case that was coming to thernhospital and clinic during the study period with type of disease to achieve the objective of the studyrnwas purposively sampled, diagnosed, surgical treated and followed up until the final outcome of therncondition. Twenty-two cases were studied and compiled based on scientific surgical case reportrnpublishing format where case history, clinical examination, surgical treatment, postoperative care,rnpostoperative complications and surgical outcomes of diseases were recorded. Accordingly, thernfindings of each case were discussed in relation to the finding of other literature. The twenty-tworncomplied case studies include 6 cases on cattle (traumatic ruminal fistula, dystocia, horn fracture,rnfibroma, paraphimosis and uterine prolapse), 7 cases on small ruminants (inguinal hernia, tibiarnfracture, obstructive urolithiasis, abscess, a hyena bite, and two limb amputation), 5 cases on smallrnanimals (dystocia, forelimb amputation, ovariohysterectomy, castration and tail amputation), 3 casesrnon equines (ventral hernia and two castration) and 1 case on swine (castration). From the totalrnhanded cases, postoperative complications were encountered in eight (36.6%) patients with recoveryrnand one patient died. The occurrence of these postoperative complications might be associated withrnlack of owner commitment to care animal as per advised, nonexistence of aseptic operation theater,rnscarcity of anti-inflammatory drugs, irregular administration antibiotics and dressing wound siternwith antiseptics. Indicates cares including pain relief, care of animal by owner per advised, asepticrnoperation theater, administration of antibiotics and dressing of incision site with antiseptics as perrnprescription may a play important role in decreasing postoperative complications and mortality ofrnpatients after surgical treatment.