Background: Laryngeal mask airway is a simple supra-laryngeal device which is used tornestablish and maintain air way. Maintaining airway is maintaining patientâ€™s oxygenation andrnventilation which is vital in anesthesia practice and for patientâ€™s life. Propofol is the mostrncommon induction agent for LMA insertion but has side effects on cardiovascular andrnrespiratory systems. And it is not available in all countries. rnObjective: To compare effects of Thiopentone with Lidocaine versus propofol for LMArninsertion for elective surgical patients at Minilik II hospital, Addis Ababa, Ethiopia fromrnDecember1, 2018 to April,30, 2019.rnMethods: An institutional based observational prospective cohort study was conducted on eightyrneight eligible adult patients at Minilik II referral hospital from December, 2018 to April30, 2019.rnThe study participants were allocated in to Thiopentone-Lidocaine and propofol group. T-Lrngroup (n =44) and P group (n =44). Data was entered in to Epi info version 7 software byrninvestigator and transported to SPSS version 23 program for analysis. Normality of the data wasrnchecked by Shapiro wilk test and histogram. Independent t- test was used to determine the meanrndifferences between two groups. For non-parametric tests Chi square test was used. And whenrnappropriate fisher exact test was used. Those variables with p-value < 0.05 were considered asrnstatistically significant.rnResults: The overall insertion score was comparable in both the groups. Excellent insertion scorernwas 33(75%) and 36(81.8%) in T-L and P group respectively. Satisfactory was 9(20.5%) in T-Lrngroup and 8(18.8%) in P group. (p=0.34). A significant fall in mean arterial pressure was notedrnin Propofol group at 1,2and 3 minutes following LMA insertion. At 1 min after LMA insertion itrnwas (84.61Â±9.8) vs (72.25 Â±11.16), p