A multistage cross sectional serological study, questionnaire survey and participatory appraisal were conducted on contagious caprine pleuropneumonia (CCPP) from October, 2007 to April, 2008 in Borana and Guji lowlands, Southern Ethiopia, to determine the prevalence of the disease, to identify the risk factors for the occurrence of the disease and to assess the perception of the community on CCPP in particular and other goat diseases in general. A total of 951 serum samples (900 from goats and 51 from sheep) were collected and tested using Complement Fixation Test (CFT). Questionnaire surveys were conducted with 69 randomly selected households. Participatory disease appraisal was done with 12 informant groups in 12 different villages, the group size varying from 5-12 informants and with a total of 120 informants. Out of the 900 goat sera samples tested, 119 (13.2%) were seropositive for CCPP, giving an overall seroprevalence of 13.2 % (95%CI=11.0%-15.4%) in the study areas. A seroprevalence of 18.3% (95% CI=14.3%-22.7%), 11.7% (95% CI=8%-15.2%) and 9.7% (95% CI=6.3%-12.6%) were recorded in Liban, Teltale and Moyale Districts, respectively. The seroprevalence recorded among the districts was significantly different (p