Effect Of Prophylactic Ondansetron On Prevention Of Spinal Anesthesia Induced Hypotension Among Women Undergoing Elective Cesarean Section At Yekatit-12 Hospital Ethiopia 2019 Prospective Cohort Study

Background: Hypotension is a common side effects after spinal anesthesia which associate withrnboth maternal and fetal morbidity. Many interventions have been suggested to prevent thisrnclinical problem. A commonly used antiemetic, ondansetron, can be used as an alternative tornprevent hypotension after spinal anesthesia. The action believed to inhibit Bezold-Jarisch reflex. rnObjective: To assess effect of prophylactic ondansetron on spinal anesthesia inducedrnhypotension among women undergoing elective cesarean section at yekatit-12 hospital, fromrnOct, 2019 –Jan, 2020, Addis Ababa, Ethiopia. rnMethodology: In this prospective cohort study 100 patients with American Society ofrnAnesthesiologists (ASA) status class-II, age≥18 and BMI 18 -30 kg/m2 who underwent cesareanrnsection under spinal anesthesia were included. Prophylactic group (n=50) receive 4mgrnondansetron, while Non-prophylactic group (n=50) did not receive ondansetron. The outcomesrnof the study were the incidence of hypotension, nausea, vomiting and the need of rescuernvasopressor. Comparisons of variables between study groups were done using student t test andrnChi square test. Significance was determined at P value

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