Comparison Of Hemodynamic And Analgesic Effect Of Pre Mixed Versus Sequential Administration Of Intrathecal Fentanyl With Hyperbaric Bupivacaine On Patients Who Undergo Elective Cesarean Section.

Background: Spinal anesthesia (SA) is the most commonly used thechiniqe of anesthesia forrnelective cesarean section. The main drawback of Spinal anesthesia is hemodynamic instabilityrnand short duration of analgesia. To minimize this draw back adding opoids like fentanyl eitherrnpre mixed with local anesthetics or sequentially with separate syringe become common practice.rnBut pre mixing alters their density and then their analgesic and hemodynamic effect. rnObjective: To compare the hemodynamic and analgesic effect of sequential versus pre mixedrninjection of intrathecal fentanyl with hyperbaric bupivacaine for patients who underwent electivernCS under SA at Empress Zewiditu memorial hospital from January 01 to March 30, 2020 G.C. rnMethod: Institutional based prospective cohort study was employed on 66 parturients whornundergone elective cesarean section under SA fulfilling the inclusion criteria. Those who hadrnreceived pre mixed technique were grouped as (M-group) and those who received sequentiallyrnwere grouped as (S- group). Data was collected perioperatively at different time interval. Basedrnon normality assumption, analysis was done by independent t test for normally distributed data,rnMann –Whitney U test for non-normally distributed data and xrn2rn test for categorical variable. Pvaluern

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