Introduction: Foot is a complex anatomical and biomechanical structure. There are 26 bones, 33rnJoints, more than 100 ligaments, tendons and muscles in each foot. The biomechanics of diabeticrnfoot is different from that of the non-diabetic foot. Changes in foot posture and architecture as arnresult of the diabetics impact on the normal biomechanics of walking and weight bearing on thernfoot. rnAim of the study: This study was conducted to assess and compare Anatomical and mechanicalrnfoot change in individuals with diabetes mellitus type-1 and type-2 in Mizan-Tepi Universityrnteaching hospital, Bench-Sheko zone, South-west, Ethiopia. rnMaterials and Methods: Institutional based cross sectional comparative study was conductedrnfrom June 1rnstrn 2019 up to November 30rnstrn, 2019 in Mizan-Tepi university teaching Hospital. Thernstudy participants were selected by using double population proportion formula samplingrntechnique, who were 294 people diagnosed as diabetics (Type-1 and Type-2). Besides, data wererncollected by using structured questionnaires and diabetic foot assessment checklists. rnResults: One hundred seventy-eights (60.5%), were males with the mean age (Â±SD) 43 (Â±14. 5)rnYears. 63.2% were illiterate, 19.4% completed primary school, 11.6% completed secondary rnschool, and 5.8% were university graduate. Out of 294 participants with DM, 31.3% were obesernor overweight, and 33.7% were diagnosed in the past 6-10 years. Among the study participants,rn32.6% had PN, 22.5% had PAD, 55.1% had DFUs, and 46% had a deformity (15%rnClawhammer toe, 12.3% hallux valgus, 11% callus, and 8.2% pes cavus). Around 62.3% hadrngood knowledge and 55.6% had identified good practice of DM foot care. rnConclusion: The current study showed that Type-2 diabetes patients have higher prevalence inrndeveloping diabetes related foot complications (like Clawhammer toe, Hallux valgus, Callus,rnand pes cavus). However, Type-1 diabetes patients have increment in understanding the effectsrnof diabetes on foot health and identifying appropriate foot care practice mobility as compared tornType-2 diabetes patients. Therefore, understanding foot mechanics is an important component ofrnthe examination and overall care of diabetic foot.