Introduction: Dermatoglyphics is the scientific study of the skin ridge patterns on the fingers, palms andrnsoles of human. Dermatoglyphics patterns are genetically determined and affected by physical,rntopographical and environmental factors in intrauterine life. There are lines in the palm known as palmarrncreases. A normal human palm contains three major creases. The patterns of the epidermal ridges andrnpalmar creases serve as a diagnostic tools in a number of diseases that have genetic backgrounds.rnDiabetes mellitus is one such of diseases with a strong genetic basis and certain dermatoglyphics andrnpalmar crease variations are expected to occur. rnObjectives: The aim of this study is to determine the prevalence of digital dermatoglyphics and palmarrncrease patterns of the hand among diabetics and non-diabetics patients in governmental hospitals, EastrnGojjam zone, 2019 rnMethods: Institution based cross-sectional study was conducted by both observation and interviewrnmethods. Bilateral palmar and fingerprints were taken by mobile camera from selected volunteers ofrndiabetic and non-diabetic subjects attending East Gojjam zone government hospitals. A Pearson chisquarernrntest, bivariable, and multivariable multinomial logistic regression models were employed usingrnSPSS version 20. Odds ratio with 95% confidence interval was computed and p-values less than 0.05rnwere considered significant. rnResult: In both diabetics and non-diabetic subjects loop type was the most frequent followed by whorlrnand arch types. Their prevalence were respectively 66.9% [95% CI: 65.4, 68.3], 28.4% [95%CI: 27, 29.8],rnand 5.1% [95% CI: 4.1, 5.4] in diabetics and 63.4% [95% CI: 61.9, 64.8], 32% [95%CI: 30.5, 33.4] andrn4.7% [95% CI: 4.0, 5.3] in non-diabetic subjects. Being male was nearly 1.4 times likely to have looprntype (AOR= 1.385 95%CI 1.120, 1.714) and whorl type (AOR=1.359 95%CI 1.090, 1.696) than archrntype of dermatoglyphics patterns. Normal type of palmar crease has nearly similar distribution betweenrndiabetic and non-diabetic subjects. From aberrant creases simian had a bit higher distribution in diabeticsrncompared to non-diabetics study participants. rnConclusion: The study showed that there was significant difference in the distribution of fingerprintrnpatterns between the diabetics and the non-diabetic subjects. The findings in the palm showed that normalrncrease was the most frequent creases. In addition, there was significant association with sex, body sidernand symmetryness in the pattern of fingerprint distribution between the diabetics and non-diabeticrnsubjects.