Background: Podoconiosis is neglected tropical diseases of foot; that affects barefooted rnsubsistence farmers who have long term exposure for volcanic red soils. In earlier studies therndiseases is assumed to be caused by genetic â€“environment interaction. The fact that the diseasesrnare multi factorial in origin and not all barefooted individuals develop podoconiosis initiates thernresearcher to investigate which type of foot is more liable to develop podoconiosis.rnMethodology: Comparative cross-sectional study design was conducted in Gojjam North westrnEthiopia using standard clinical (FPI-6) measurements for control groups and digitalrnradiographic (angular) measurements for cases to determine foot type. Univarate, bivarate andrnmultivariate analysis was used. rnResult: A total of 144 households with 144 members aged 18 years and above were included in the rnstudy. Almost all patients (99.0%) were in the age group 15-64 (the age group that includesrneconomically active individuals in Ethiopia), did not read or write (65.0%), and were farmers rn(87.0%). Those who are illiterate, un married were more affected by podoconiosis (AOR = 3.378,rnp=0.079 and AOR = 8.664, p = 0.027). The average monthly income is the other finding which isrnassociated with podoconiosis development (AOR =0.999, p< 0.001). Individuals who were shoesrnearly in their life are less likely to develop podoconiosis (1.075, p = 0.018). The population withrnlow and high arched are more likely to develop podoconiosis (AOR = 2.096 and AOR=15.383)rnrespectively. rnDiscussion: In our study low and high arched community members who are above age eighteenrnare more likely to develop podoconiosis. This may be the low arched foot exposes individuals inrnmore surface area to volume ratio for the ground so that the chance of the silica to penetrate thernfoot will be increased where as for those who are high arched individuals the plantar pressurernbetween the foot and the ground is high than other foot types that may again give the opportunityrnfor red silica to penetrate the skin of the foot. rnConclusion and recommendation: The study winds up with individuals who have low archedrnfoot are more affected with podoconiosis than other foot types. The findings of the study alsornreassure podoconiosis affects more the poor and illiterate population than the rich and literaternpopulation. For this the researcher suggests large scale combination of foot parameters andrngenetics should be done for developing effective management of podoconiosis