Background: COVID-19 is a highly infectious disease which increases work-related andrnpsychological stress and level of burn out among front line health workers. rnObjective: To describe the prevalence of burnout among front line healthcare workers and thernassociated factors at Eka Kotebe COVID-19 treatment center .rnMethodology: Institutional based Cross-sectional study design was conducted on 200 sample rnfrontline health workers selected by simple random sampling technique. These health workersrnwere selected at Eka Kotebe COVID-19 treatment center because it is one of the nationalrnCOVID-19 treatment centers. The study participants were stratified based on their professionrn.Structured self-administered questionnaire was used. The questionnaire contains of 22 items,rnwhich includes 8 items in emotional exhaustion, 5 items in depersonalization and 9 items inrnpersonal accomplishment. Pre-test was conducted on 10% of sample in BLH to assure reliabilityrnand validityrn. Data was coded, entered and analyzed by SPSS version 26.rn rnResult: The study showed that 170(85.0%) of front-line health workers had a high level ofrnburnout ( high score of either EE, DP ).107 (53.5%) of frontline health workers had a high scorernin both EE & DP subscale. The study also showed that 41(20.5%), 54 (27.0%), and 105 (52.5%)rnfront line health workers experienced low, moderate, and high levels in the emotional exhaustionrnaxis, respectively. In the depersonalization axis, the values for low, moderate, and high levels ofrnburnout were 15 (7.5%), 17 (8.5%), and 168(84.0%), respectively. Also, 5(2.5%), 7 (3.5%) andrn188 (94.0%) health workers scored low, moderate, and high in the personal accomplishmentrnaxis, respectively. Among the studied characteristics, gender, low level of baseline jobrnsatisfaction, service year as a health care provider, and development of acute infection wasrnassociated with high levels of all three domains of burnout.rnConclusion: Burnout is prevalent among healthcare workers caring for COVID-19 patients inrnEka Kotebe COVID-19 treatment center .rnGender, job satisfaction, and year of practice as health care providers contribute to the level ofrnfront line health care provider burnout during the covid-19 pandemic at Eka Kotebe COVID-19rntreatment center.