Background: Cerebral Palsy (CP) describes disorder of movement and posture that appearsrnduring infancy/early childhood causing activity limitations that are attributed to nonprogressiverndisturbancesrnthatrnoccurredrninrntherndevelopingrnfoetalrnorrninfantrnbrain.rnAnyrnprogressivernrnCNSrninjuryrnrnoccurring during the first 2(some say 5) years of life is considered to be CP. CPrnmay be caused by prenatal, perinatal and postnatal factors.rnObjective: The Aim of this study was to assess the prevalence of cerebral palsy, determine itsrnassociated factors and Magnetic Resonance Imaging (MRI) Patho-anatomy among patientsrnattending paediatric neurology clinic of Tikur Anbessa Specialized Hospital (TASH), AddisrnAbaba, Ethiopia. rnMethod: Hospital based retrospective cross sectional study was conducted in Tikur AnbessarnSpecialized Hospital with randomly selected sample of 422 patients attending to paediatricrnneurology clinic from September 2017-Septmeber 2020. Data was collected using checklist byrnusing Kobo Collect version 1.27.3 and was exported to SPSS windows version 25 for analysis.rnBivariable and Multi variable binary logistic regression analysis were also carried out torndetermine the effect of explanatory variables. Level of significance of 5%, and adjusted oddsrnratio (AOR) with 95% confidence interval (CI) was used. rnResult: A total of 402 patients were used. The prevalence of CP was found to be 35.8% amongrnpatients who visited the paediatric neurology outpatient clinic. Twelve variables werernassociated in Bi-variable analysis, of which five variables, that is; sex, preterm delivery, homerndelivery Null parity and birth asphyxia were significantly associated with AOR 95% CI. (Sex:rn1.89[1.11-3.25], preterm: 7.04[1.55-31.82], home delivery: 7.74[1.66-35.95], null parity:rn1.7[1-2.9], asphyxia: 4.47[1.76-11.29] respectively). Among the CP cases spastic CPrnaccounted for 88.9% and 62.5% were quadriplegic.58% of CP the patients were reported tornhave predominant white matter injury. rnConclusion and recommendation: The prevalence of CP in the present study is lowerrncompared to that reported by other African researches. The most significant risk factors forrndeveloping CP were perinatal factors such as asphyxia, home delivery and preterm delivery.rnAmong the clinical types spastic quadriplegic type is the commonest and most of the patientsrnare at level 5of Gross Motor Function Classification System (GMFCS). Predominant WhiternMatter Injury was found to be one of the commonest MRI finding. rnMost of the factors associated are preventable perinatal problems which can be reduced byrndecreasing complications during birth, better health care during pregnancy, delivery andrnpostnatal period.