Oral contraceptives are widely used and are generally safe and effective for many women. Oralrncontraceptives are known also as the Pill, POP, COCPs, OCs, BCs, BC tablets, or birth controlrnpills. This medicine usually contains two types of hormones, estrogens and progestins and,rnwhen taken properly, prevents pregnancy.rnThe aim of this project is to review and present the teratogenic effects of Oral contraceptivesrnon the limb development.rnAllegations that inadvertent pregnancies occurring in users of contraception are associated withrncongenital anomalies are common. Fortunately, there is little to no scientific basis for suchrnclaims. Evaluating these claims requires consideration of the two general mechanismsrnresponsible for human malformation: teratogenesis and mutagenesis.rnSome study indicate that there is a possibility of a sevenfold (7X) increase in risk of limbrnreduction defects, Other authors concluded that, exposure to sex hormones during pregnancyrndoubled the risk for some specific diagnoses, including certain limb defects, but these increasesrnwere not statistically significant.rnInbred normal adult SWR mice were used to investigate the possible teratogenic effect ofrnMicroginon 30 (0.15mg leronogestrel (L) + 0.03mg EE), as an oral contraceptive on fetuses ofrnfemales receiving doses from day 7 to day 12 of pregnancy. External malformations includingrnabnormal hind limb, abnormal tail and exencephaly have been induced in low frequencies byrnthe doses 0.48L + 0.96E and 1.20L +0.24E mg/kg.rnAn analysis of available epidemiologic data leads the present reviewer to conclude that the usernof exogenous hormones during human pregnancy has not been proved to cause developmentalrnabnormality in non-genital organs and tissues. If there are increased risks of non-genitalrnmalformations associated with the administration of certain sex steroids, the risks are veryrnsmall, may not be causal, and are substantially below the spontaneous risk of malformations.rnKey words: Oral contraceptive, congenital limb reduction defects, pregnancy