Background: A complaint of postoperative pharyngeal discomfort is so prevalent that it isrnalmost expected by patients and anesthetist alike as an unavoidable part of routine anesthesia.rnComplaints range from a minor throat irritation to debilitating pain, inability to swallow andrntemporary voice changes, and are a frequent observation on the postoperative visit. There is norndata regarding the magnitude of post-operative airway complications and their associated riskrnfactors in Ethiopia.rnObjective: The purpose of this study is to assess the magnitude and possible associated riskrnfactors for postoperative sore throat following surgery by general anesthesia with endotrachealrnintubation.rnMethods and materials: Institutional based crossectional study design was conducted inrnBlack Lion Hospital Addis Ababa, Ethiopia from February 1-30, 2016 in patients aged 18rnyears and above who underwent surgery under anesthesia with endotracheal intubation usingrnstructured questionnaire prepared on variables being measured. Bivariate analysis and binaryrnlogistic regression was used to measure association between dependent and independentrnvariables. Pvalue 0.05 was used as cut off point.rnResults:Out of 114 patients who had elective surgery by anesthesia with endotrachealrnintubation, 52(45.6%) of the study participants complained of various forms of post-operativernthroat complaints. In this study it was found that size of ETT showed statistically significantrnassociation with the post-operative sore throat with p-value 0.001, (AOR- 0.214, 95% CIrn0.090-0.512) and the duration of anesthesia/surgeryalso showed statistically significantrnassociation with POST with p-value 0.014, (AOR 0.14, 95% CI 0.029-0.676).rnConclusion and recommendation:The findings of this study confirmed previous observationsrnthat the larger the ETT size, the higher the incidence of postoperative respiratory morbidities.rnAlthough tracheal intubation remains an absolute necessity for good airway protection forrndifferent surgical procedures, we recommendedto use the smaller ETT sizes (6.5, 7.0 mm ID) tornminimize the pressure-induced trauma on the laryngeal and tracheal mucosaernrnKey words: -Post operative sore throat, Endotracheal tube. surgery