The purpose of this study is to assess the effects of employee’s commitment on Quality Management System (QMS) Implementations, a continual improvement practice, in the case ofEthiopian Pharmaceuticals Supply Agency. The study was conducted based on derived Three Component Model (TCM) of employee commitment to quality. Both descriptive and explanatory research design and both quantitative and qualitative research approach was utilized. A questionnaire was administered to EPSA employees working in two EPSA hubs and central EPSA and the respondents were selected by using stratified sampling method. The collected data was analyzed using SPSS software version 22. In addition, Nonparametric Kendall's Tau-B correlation and Generalized Linear Regression model were used. The Affective commitment, Behavioral commitment, and Cognitive Commitments have significant monotonic relationships or correspondence with Quality Management System Implementations (QMSI). There is a considerable effect of overall employee’s commitment onthe quality management system implementations (QMSI) in the organizational operations of EPSA, have different influencing extents on QMSI in the three dimension of employee commitment, while Affective commitment have the most significant effect on QMSI. It is recommended that EPSA’S employee commitments need critical attentions in the quality management system implementations (QMSI).