Studies On First Rowtransition Metal Complexes Derived From Ninhydrin And Amino Acids Having Polar(threonine) And Nonpolar(leucine) Side Chains

Complexes of Co(II), Ni(II), and Zn(II) with Ruhmann’s purple, those of Fe(III) and Mn(II) with anrnintermediate Schiff base ( ketimine and / or aldimine) and Cu(II) with ninhydrin were successfullyrnsynthesized. All complexes were distinctly colored and stable to atmospheric conditions. Therncomplexes were characterized by elemental analysis, molar conductance, magnetic susceptibility,rninfrared and electronic spectral studies.rnThe ligands were shown to behave as a monobasic tridentate ONO, bidentate ON or OO donor.rnThe complexes of Zn(II), Co(II) and Ni(II) are purely Ruhmann’s purple, those of Mn(II) andrnFe(III) are Schiff base (ketimine), Schiff base and ninhydrin or Schiff base and Ruhmann’s purplerncomplexes. An octahedral geometry is proposed for all of the metal complexes, except Mn(II).rnA comparative anti- microbial study of the complexes was undertaken against two gram - negativernbacteria, Escherichia coli and one gram - positive bacterium Staphylococcus aureus. It wasrnrevealed that except Cu(II) and to some extent Zn(II) complexes most of the complexes exhibit arnreduced activity against both bacterium.rnKEY WORDS: metal complexes, Schiff base, ninhydrin, Ruhmann’s purple,rnᾳ– Leucine, ᾳ–L–Threonine and antimicrobial activity

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