Background:Coronavirus disease 2019 (COVID-19) pandemic has infected 173,674,509 peoplernglobally resulting in 3,744,408 deaths as of 09 June 2021.Ethiopia is categorized under COVID19rnrnepidemic phase III (advancing outbreak). There are global concerns and predictions thatrnCOVID-19 would severely affect tuberculosis (TB) and HIV care and treatment services inrnresource-constrained countries. rnObjective: To assess the real-time impact of COVID-19 on TB and HIV care and treatmentrnservices in Addis Ababa, Ethiopia. rnMethods: This was a facility-based, multicentre, cross-sectional study in 10 health centers withrnhigh TB/HIV patients in Addis Ababa, Ethiopia. Participants were patients with TB and/or HIVrnwho have been attending TB and/or HIV clinical care and treatment in the study sites in thernCOVID-19 pandemic period. Data were collected using adapted, interviewer-basedrnquestionnaires to investigate the impact of COVID-19 in their routine care and treatmentrnservices. Data were entered into Epi Info version 7 and exported to SPSS version 26 for analysis.rnVariables with a P-value â‰¤ 0.25 in the bivariate analysis were included in the multivariaternlogistic regression. Statistical significance was declared if P-value < 0.05. rnResults: The study included a total of 424 informed and consented participants.Studyrnparticipants who missed appointments for medication refill were 98 (23.1%).When the effects ofrnother independent variables on appointments/visits for refill were controlled,the followingrncharacteristics were found to be the most important pridictors of missed appointments (P