The Kombolcha to Desse road, linking Addis Ababa with Northern Ethiopia towns traversesrnthrough one of the most difficult mountainous ranges in Ethiopia. Slope instability problemsrnin the form of rock fall, rotational failure of colluvial material and debris slides are therncommon events in the area on the sides of the main road. The presence of loosernunconsolidated materials (colluvial materials), highly weathered and fractured basalt rocksrnhigh relief, steep natural slopes, nature of geologic formations exposed along the roadrnsection, poor drainage conditions, occurrence of high seasonal rains, and seismically activernnature of the region created favorable condition for slope instability in the area. Thus,rnkeeping in mind all above points the present study was conceived to study in detail the slopernstability condition of the area. It was realized that detailed slope stability studies along thisrnroad section are very necessary to identify critical slopes and to provide the best remedialrnmeasures to minimize the slope instability problems which frequently disrupt and endangerrnthe traffic movement on this important road.rnFor the present study based on the field manifestation of instability two most critical slopernsections were identified for detailed slope stability analysis. The deterministic slope stabilityrnanalysis approach was followed to perform the detailed slope stability analysis of the selectedrnslope sections. Factor of safety for the selected slope sections was determined for therndifferent anticipated conditions (i.e., static and dynamic with varied water saturations) usingrnSlope/W and Slide software. Both static and seismic slope stability analysis was carried outrnand factor of safety was deduced for each anticipated conditions. In general, detailed slopernstability analysis of the two critical slope sections reveals that for only static dry conditionrnboth the slopes sections would be stable. However, for the rest anticipated conditions definedrnby static and dynamic situations with varied water saturations both critical slope sectionsrnwould be unstable.rnMoreover, the causes of slope instability in the study area are governed by different factors;rntherefore integrated approaches of remedial measures are more appropriate to mitigate thernpossible slope instability in the study area. Depending on site condition and slope stabilityrnanalysis result four types of suitable preventive and remedial measures are recommendedrnnamely; proper managements of drainages, retaining structures, gabions, and managingrnsteeply cut slopes.rnKey words: Slope stability analysis, Sensitivity analysis, Factor of safety, Remedialrnmeasures, Static and Dynamic condition.