Motivation is one of the most important tools of human resource management. Organizationsrndesign motivation systems to encourage employees to perform in the most effective way but alsornto attract potential candidates. The key to create the efficient motivation system is an answer tornthe question what really motivate employees. The main objective of this study is to assess thernteachers work motivation and job satisfaction to identify the variables which are the mostrnpredictor of teachers’ work motivation and satisfaction in secondary schools of Assosa Zone. Tornaccomplish this purpose, the study employed a descriptive survey research design. The study wasrncarried out in randomly selected nine secondary schools of Assosa Zone. A total of 166rnindividuals participated in the study. Among them, 149 teachers were included as samplesrnthrough random sampling technique. Additionally, 9 secondary school principals, 4 clusterrnsupervisors and 4 Woreda education office coordinators were included through availablernsampling technique. Questionnaire and interview were the main instruments of data collection.rnThe analysis of the quantitative data was carried out by using mean and standard deviations.rnThe findings revealed that the school practices on the independent variables that influencernteachers’ work motivation and job satisfaction are insufficient as most of the practices onrnindependent variables scored below two, when it serves as the average of the likert scales. As arnresult teachers are not encouraged to disseminate their knowledge to students through effectivernteaching-learning method, to achieve schools objective as well as to stay in the profession. Duernto this teachers are not successful to improve the students’ academic achievement as well asrnschool goals. In general, the findings revealed that, secondary schools in Assosa Zone had notrnworked effectively on improving the motivation level of teachers and their job satisfaction whichrnforced teachers to leave the profession. Based on the findings, it is recommended that secondaryrnschools, Woreda and Zone education offices need to give necessary rewards, recognition,rnempower teachersrn,rnprofessional development, strength staff relationship and furnishing thernworking conditions with refreshment facilities.