The purpose of this study was to assess the practices and challenges of human resource management in the case of administrative support staff at the school of commerce, Addis Ababa University. Three basic questions were formulated, which emphasized the extent to which all the sample stakeholders understand about the issue under investigation. In order to meet the objectives of the study, descriptive survey design was employed. Questionnaire was used as main tool of data collection. Interview and document analysis were used to substantiate the data gathered through questionnaires. Frequency, percentage, mean value and standard deviation were utilized to analyze quantitative data gained through the questionnaires. The qualitative data gathered thorough interview and document analysis were analyzed by narration. The unit of analysis for this study is school of commerce was sampled purposively, while respondents are randomly selected among supportive staffs from the school of commerce. The findings of this study revealed that less participation rate of female supporting staffs at Addis Ababa University, School of Commerce were observed and majority of the supporting staffs were relatively energetic, matured and fit to take responsibilities. Besides, employees with the mean and SD value respectively (X=3.19, SD=0.92) confirmed that School of Commerce has written human resource practice and principles such as selection, promotion, termination and implemented periodically. The study also identified the sample employees moderately agreed that trainings are important in improving the employees’ performance to give quality service. Finally the mean as well as SD value of (X= 3, 91, SD=1.05) respectively confirmed that the majority of the respondents agreed and rated as a great extent and they underlined that recruiting skilled employee is timely issue and mandatory as well. Besides, there was slight difference and variation among the opinions of the sample respondent. Furthermore, performance appraisal process were implemented modestly depends on the employees’ actual performance and the feedback practices which is given to employees after performance appraisal was fairy undertaken. And the study participants have confirmed that they all actively involved in formulating rules and regulations and planning & preparing school budget. Finally, the school of Commerce is advised to update its employee’s skills and knowledge through training and leadership development to cope with technological advancement and competitive environment and capacitate the ability of its employees as long as efficient and effective implementation human resource management practices concerned.rnKey Words: Human Resource Management, Supporting staff and School of Commerce