Resilience is defined as the individual's ability to bounce back from trauma. This study aimed to evaluate the level of resilience and its predictors among cancer patients undergoing cancer treatments in Tikur Anbessa Specialized Hospital. Explanatory quantitative study design was conducted with 284 cancer patients who took at least one chemo and/or radiation therapy between August 15 to September 15, 2019. Stratified and simple random sampling methods were used to select the study participants. Respondents were assessed using the Connor-Davidson Resilience Scale (CD-RISC) 10 item version, revised intrinsic/extrinsic religious orientation Scale, the multidimensional scale of perceived social support, selfefficacy for managing chronic diseases 6-item Scale, Herth Hope Index (HHI), Emotional Regulation Questionnaire (ERQ) and demographic and disease-related information. Descriptive statistics, bivariate analyses (independent samples t-test, one way ANOVA and Pearson correlation) and multiple hierarchical regression were conducted to explore predictors for resilience. The mean score on the CD-RISC-10 was 31.84 (SD=5.92). Among the tested variables, the study found that gender, educational level, employment status, treatment cycle, family support, intrinsic religious orientation, external social religious orientation, cognitive reappraisal, and hope had a significant positive relationship with resilience and tumor stage had a negative relationship. Multiple hierarchical regression analysis indicated that hope (Î² = 0.36, P