Background: The purpose of this study was to describe current tube feeding knowledge and rnPractices and associated factors to aim appropriate quality improvement interventions. ThernSynergy model of patient care was used as a conceptual basis for this study. rnMethods: A cross-sectional study was used to assess knowledge and practice of enteral nutritionrnamong nurses who works in ICUs of governmental hospitals in Addis Ababa city, Ethiopia. Arntotal of 209 nurses that met the inclusion criteria, 192 (92% response rate) responded to thernquestionnaire. A self-administered data collection method was used and undertaken on Mayrn2019. rnResults: More than three fourth 167 (87 %) of respondents had poor knowledge of enteralrnnutrition and the result revealed that only 21(11%) have good practice. Participants who are firstrndegree holder were less likely to had adequate knowledge by 76/100 than MSc. Holders. (AOR =rn.240, 95% CI: (.61, .936). rnParticipants in the age group of 20-28 were less likely to had good practice by 98% on enteralrnnutrition than age group of 46-61 (AOR = 0.023, 95% CI: (0.001,0.523). and nurses who got inrnschool nutrition training were 2 times higher to had good practice on enteral nutrition than didnâ€™t rngot. (AOR = 1.951, 95% CI: (.063, .601). Also participants who were aware of protocol had 3rntime of good practice than not aware of protocol about enteral nutrition. (AOR =3.401, 95% CI:rn(1.186, 9.789) rnConclusions and recommendation: Although the improvement of nurses' knowledge andrnpractices regarding enteral nutrition will directly or indirectly lead to reduce the complicationsrnand side effects related to enteral feeding in the critical care units, Nurses have remarkable gapsrnand alarming skill performance related NGT feeding. Therefore periodic on-job and pre-servicerntraining regarding enteral nutrition , guidelines as well protocol should be provided to all ICUrnnurses and regular supportive supervision by experts is also needed to sensitize, update andrnmotivate staffs to provide safe nutritional support in all intensive care units s.