BackgroundrnCardiopulmonary arrest is a major public health problem. Cardiopulmonary resuscitation (CPR) isrnan important life-saving technique, consisting of chest compression and rescue breathing and usedrnto treat victims of cardiopulmonary arrest by helping to maintain oxygenated blood circulation inrnthe body. The chance of survival after cardiopulmonary arrest may be increased with quality CPRrnthat mainly depends on the sufficiency of the knowledge, attitude and skill/practice of healthrnprofessionals who deliver the CPR. Therefore assessing the knowledge attitude and practice andrnassociated factors among medical interns of Tikur Anbessa Specialized Hospital and Yekatit 12rnHospital Medical College in performing CPR is important as they manage many trauma andrncritically ill patients.rnMethods: A cross sectional study conducted from March 2020 to July 2020, among 169 medicalrninterns of TASH and 49 medical interns of YHMC. Structured questionnaires of 2020 Americanrnhealth association guidelines for CPR and basic life support (BLS) Practice Test of NationalrnHealth Care Provider Solutions of 28 questions were used to assess the knowledge, attitude andrnpractice and associated factors in performing CPR among study participants who fulfilled therninclusion criteria. rnResults: The mean for knowledge score of TASH and YHMC medical interns were 6.36 + 1.77rn(49.00%) and 6.51 + 1.72 (49.83%) respectively whereas the mean for the practice score ofrnTASH medical interns was 5.49 + 1.57 (55.10%) while that of YHMC medical interns was 4.86 +rn1.55 (47.91%).This is statistically not significant as P-value is greater than 0.05. Factors likerninstitutions where they were training internship, having formal lectures, role plays, practices andrnlearning from guidelines, MICU/PICU/ER attachments, age & sex of the study participants, hadrnsignificant association with CPR practice among medical interns in the study area.rnConclusions: This study identified that the knowledge and practice score of CPR which is poor inrnboth schoolsâ€™ medical interns and significantly associated with lectures, role plays, practicesrnguidelines, MICU/PICU/ER attachments and age and sex, even though they have positive andrngood attitude towards it. Structured CPR training should be part of the curriculum to solve thisrnissue.