ABSTRACT rnBackground: COVID-19 is a respiratory tract infectious disease caused by severe acuternrespiratory syndrome, coronavirus 2 (SARS-CoV-2), which is the offspring of the strain SARSCoV-1rnthatrncausedrnthernoutbreakrnofrnSARSrninfectionrnfromrn2002rntorn2004.rnAsrnofrnDecemberrn15,rn2020rnrnworldrnrnhealth organization global aggregate report 70 million and 1.6 million COVID-19rnmorbidities and mortality were registered respectively. Meanwhile, the burden of the situationrnhas resulted in the health system's shortage of health care workers, and in this context, thernparticipation of medical students on the front line is obligatory. In addition, as with any sectionrnof of the society, it is important to evaluate the knowledge, precautionary measure, and attitudernof medical students as long as they are at risk. Therefore, applicable training regarding COVID19rnis anrnurgentrnprerequisiternthatrnuniversitiesrnandrnhealthrnsystemsrnmayrnassure.rnrnObjective: The objective of this study was to assess the knowledge, attitude, and precautionaryrnmeasure towards COVID-19 among medical students in Addis Ababa, Ethiopia 2021.rnMethods: A cross-sectional study was conducted in randomly selected Addis Ababa medicalrnschools on a sample size of 371 students. The data was collected from April to May, 2021, usingrnpretested and structured self-administered questionnaire. Fully completed data were entered intornEpi-Data manager V-4.6 and were exported to SPSS V-26 for further analysis. Finally, the datarnwas computed as means, standard deviation, and summarized as frequencies and proportions.rnAssociation between independent and dependent variables was assessed using bivariable andrnmultivariable logistic regression, and P-Value