IntroductionrnSeptic shock is a major healthcare problem, affecting millions of people around the world eachrnyear, killing one in four and increasing in incidence. In most developed countries, the incidencernof Septic shock has been identified as between 50 and 100 cases per 100,000 people in thernpopulation. The mortality rate from severe sepsis in the developed countries has been estimatedrnas being between 28 and 50%, ranging from 15% in patients with sepsis and up to 40-50% inrnpatients with septic shock with multi-organ dysfunction syndrome (MODS)rnObjectivernThe study aims to explore the incidence and the factors associated with outcome among patientsrnwith septic shock admitted to the intensive care unit, TASH, Addis Ababa, Ethiopia.rnMethodrnA retrospective cross-sectional study was carried out at intensive care unit of our hospital. Thisrnstudy included all patients with septic shock admitted to adult ICU of TASH during Jan 2014-rnDec 2017. Data was collected using a structured checklist and statistical analysis was done usingrnSPSS version 21. Regression model was applied to identify the factors contributing to thernoutcome of septic shock. P-value less than 0.05 were considered statistically significant.rnResultsrnOf 820 admissions, 115 (14%) patients had septic shock. Majority (60%) was female and thernmean age was 47.9+16.5 years. The most common sites of infection were the respiratory tractrninfection (54.8%) followed by urethral tract infection (14.8%), Gram-negative bacteria,rnparticularly Escherichia coli (4.3%) and Klebsiella pneumonia (3%), were the major infectingrnmicro-organisms. All patients have received antibiotic and fluid therapy. 23.5% patients startedrntreatment within the first hr. of ICU stay and the overall 28-day mortality rate was 58.3%.rnConclusionrnThe study revealed that septic shock is a frequent cause of ICU admission with a high mortalityrnrate. This can be explained by the fact that septic shock patients have more comorbidity, a worstrnprevious state of health and requires more life support therapies. Therefore early identification ofrnhigh risk population, implementation of appropriate treatment and the design of future clinicalrnstudies are crucial to improve the outcome of septic shock