Background: Poisoning exposures continue to be a significant cause of morbidity andrnmortality worldwide. The lack of facilities, treatment resources, and antidotes in hospitals mayrnaffect the treatments provided and outcomes.rnObjective: Assessment of availability of treatment resource in emergency department for thernmanagement of acute toxic exposures and poisoning detection in selected governmentalrnhospitals, Addis Ababa, Ethiopia.rnMethodology: Hospital based descriptive cross sectional study was applied to assessrnavailability of treatment resource for the management of acute toxic exposures and poisoning inrnselected governmental hospitals from December 2016 to June 2017. Data were collected usingrnsemi-structured questionnaire and the data obtained was analysed using SPSS and the result wasrnpresented using tables Chart and graph.rnResult: Over the study period, 920 poisoning cases were listed in the selected hospitalrnregistries. Among them, Organo phosphate poisoning was the most top leading cause of acuternpoison (18.8%, 173/920), Followed by Bleach (Sodium hypochlorite) poison (18.6%, 172/920).rnIn all the hospitals all form of Charcoal and Sodium Sulphate were not available. Four of the fivernhospitals have had Orogastric tube and magnesium Sulphate. Only Nasogastric tube out of thernten decontamination resource had available in all hospitals. None of the studied hospitals havernthe stock of all either WHO or Ethiopian essential drug list recommended antidotes and none hadrnfomepizole, pralidoxime, charcoal, sorbitol, ipecac, polyethylene glycol, deferoxaminerndimercaprol, glucagon, and Protamine sulphate. In surveyedrnhospitals peritoneal dialysis wasrnnot available.rnConclusion: For the majority of the surveyed hospitals the resources which are essential forrntreatment and management of poisoned patient are not sufficient. Furthermore, the availablernresources and the pattern of causes of poisoning show discrepancy.rnRecommendation: Based on the pattern of causes of poisoning it is better if the selected anti-rndotes, stabilization, decontamination and elimination resource are available.rnrnKeywords Decontamination _ Elimination enhancement _ Stabilization resources _Availability_ Hospital _ Ethiopia _Poisoning.