Drinking Water quality deterioration in most towns of the country due tornvarious anthropogenic activities and poor sanitation make the communityrnto depend on unsafe and poor water consumption, these expose therncommunity for health and other water quality associated risks. Importancernof Beressa River is strongly linked to domestic consumption, irrigation,rnindustrial pollution and public health. By far it is the only perennial riverrnserves the surrounding community as major source of drinking water.rnAssessing the drinking water quality of the river is crucial for therncommunity and the surrounding environs. This is the reason that suchrnwater quality assessment on river Beressa was conducted.rnTo assess the water quality of Beressa River in Debre Berhanrnphysicochemical laboratory analysis were undertaken on samples from sixrnrepresentative sampling points for four months from November tornFebruary.rnThe physicochemical results for different parameters range for Turbidity (6-rn9 NTU), Sodium (8.6-245mg/l), Potassium (2.6-9.8mg/l), Bicarbonatesrn(98.87-178mg/l), Sulfate (0.8-120mg/l), Ammonia (0.14-10.64ml/g), pH (7-rn9.6) are the major drinking water quality concern in Beressa River.rnThe result obtained revealed that the physicochemical parameters showrnvariation among sampling points. Most water samples taken from thernindustrial areas of Debre Berhan blanket factory and tannery show highrnlevel of water contaminants that do not fulfill the WHO and draftrnEthiopian drinking water standards where as sampling points far fromrnsuch area are in good condition.