Today, increasing population and rapid development are resulting for generation of large amountrnof solid wastes in developing countries. Most of these wastes are usually disposed in open dumpingrnsite, open spaces, rivers or burned in the streets without any treatment due to lack of properrnmanagement techniques, awareness and commitment of the society and the government, whichrncreates severe environmental pollution and health hazards, hence it was thought to attempt usernof municipal solid waste for cheap and ecofriendly treatment methods like vermicomposting. It isrnthe process of compost formation by earthworms. Optimization of process parameters for the vermicompostingrnof municipal solid waste using Esenia fetida was investigated using response surfacernmethodology (RSM). The three parameters and their ranges namely moisture content (60-90%), C/Nrnratio (20-30), and worm stocking density (0.8-2.0 kg/m2) were chosen from the previous study ofrnvermicomposting. The experimental data on the quantity of N, P and K were fitted into a quadraticrnpolynomial model using multiple regression analysis. The experimental results and software predictedrnN, P and K values were comparable. The individual parameters effect as well as effect ofrninteractions between the vermicomposting parameters on N, P and K was analysed using variousrngraphical representations. A three-level three factorial Box-Behnken design technique under RSMrnusing numerical optimization method was used to optimize their interactions, which showed thatrna moisture content of 74.62%, C/N ratio of 23.21, and worm stocking density of 2 kg/m2 were thernbest conditions. Under these conditions, the maximum predicted yield of N, P and K was 2.82%,rn1.58% and 1.28%, respectively. The produced vermicompost was found to be better in desired levelrnof composition of macro-nutrients i.e., N, P and K and the efficacy of the prepared vermicompostrnhas been studied on the spinach vegetable plant. A plastic pot set-up with soil was used to determinernthe effects and efficiency level of vermicompost on the yields of spinach. The study was conductedrnthrough effect of increasing concentration of Vermicompost (0% (control), 50% and 100%rnw/w) in target plant growth. Total leaves wet weight and number of leaves has been studied. Resultsrnshowed that the number of leaves produced using 100% VC was 2.67 times greater than thernnumber of leaves produced using 0% VC and 1.6 times greater than produced using 50% VC andrnleaf wet weight of the spinach plant produced using 100% VC was 2.2 times greater than producedrnusing the control (soil) and 1.2 times greater than produced using 50% VC. Thus, vermicompostingrnof municipal solid waste is an excellent and ecofriendly method of municipal solid waste management.rnKey words: Optimization; vermicomposting; municipal solid waste; Esenia fetida; response surfacernmethodology; spinach