Groundwater is treasured and very important natural resource globally. It is also thernmost essential for the development of a country. However, groundwater potential zonernmapping still remained uncertain due to the challenge nature of groundwater and alsornless studied. Therefore, this research aimed at delineating the groundwater potentialrnzone of Nili river catchment by using the integration of Geographic Information Systemrn(GIS) techniques Hence, in this estimation seven controlling factors are used as thematicrnlayer which, were derived from 30m*30m resolution Digital Elevation Model (DEM)rndata, and exiting map of geology, geomorphology, slope, drainage density and landrnuse/land cover, rainfall, and soil texture. The groundwater potential evaluation of Nilirnriver catchment utilized the above factors as an input data using weighted overlayrnanalysis and Analytical Hierarchy Processes (AHP) methods. In this analysis eachrnthematic layers were weighted, calculated and compared with different literature valuesrnof similar researches at different localities. After weighted average calculation of eachrnthematic layer, relative importance was assigned values according to AHP scale.Thernanalysis showed that groundwater potential of the study area ranges from moderatern(31.66%) to very poor (16.13%) with intermediate potentials rated as good (27.59%) andrnpoor (24.62%). The analyses revealed that most important influencing factors of therngroundwater potential zones of the study area (Nili river catchment) are geology,rngeomorphology, land use land cover and slope as compared to the other controllingrnparameters such as rainfall, drainage density and soil texture. The model result alsornindicated that good groundwater potential is associated with low slope, flood plains, croprnlands, low drainage densities and high rainfall areas. In converse, poor groundwaterrnpotentials are associated with steep slopes mainly to mountains areas, bare lands, highrndrainage densities and low rainfall areas. Therefore, this research shows vigorousrntechnique using GIS is economically affordable, technically competent and valuable forrndelineating groundwater potential zones. It is also recommended that the Nili riverrncatchment needs geophysical investigations and further wells drilled in the catchment tornget supplementary subsurface formation.