Background- Non-communicable diseases are now accountable for the majority of global deathsrnand cancer is anticipated to rank as the leading cause of death and one of the threats to escalatingrnlife expectancy in every country of the world in the 21st century. Cancer is recognized to reducernthe quality of life, thus has a negative impact not only on physiological symptoms but also on thernpsychological functioning of the individual. The objective of the study was to assess the quality ofrnlife among adult Gastro-Intestinal Cancer patients in Tikur Anbessa Specialized Hospital, AddisrnAbaba, Ethiopia, 2019. rnMethod- Institution based cross-sectional study was done in Tikur Anbessa specialized hospitalrnfrom February to April 2019 on adult Gastrointestinal (GI) cancer patients. All consecutive GIrncancer patients were included, a total of 250 participants. The validated Amharic versionrnquestioner of the European organization for research and treatment of cancer core 30 and diseasespecificrnquestionerrnforrneachrnofrnGIrncancersrnwasrnused.rnTherndependentrnvariablernGlobalrnhealthrnstatusrnrn(QOL)rnwasrndichotomizedrnwithrnarncutoffrnpointrnabovernandrnbelowrn50rnforrninterpretation.rnAssociationrnrnbetweenrneachrnvariablernwithrnQOLrnwasrnexaminedrnusingrnbinaryrnlogisticrnregression.rnVariablesrnwithrnpvaluernof