Validity Of The European Organization For Research And Treatment Of Cancer Quality Of Life Tools In Colorectal And Oesophagogastric Cancer Patients In Ethiopia 2020.

Background- Gastro intestinal cancers and their treatments have detrimental effect on patients’rnQuality of Life. The European Organization for Research and Treatment of Cancer (EORTC)rntools which had been developed to assess quality of life among colorectal and oesophagogastricrncancers patients were validated and used in different countries. However, the tools have not beenrntranslated into local language nor validated in Ethiopian context. Therefore, this study aimed tornvalidate EORTC quality of life tools in Ethiopian colorectal and oesophagogastric cancerrnpatients.rn rnMethods: Institution based cross-sectional study was done at Tikur Anbessa SpecializedrnHospital from March to May, 2020. Based on the recommendations given for multi trait scalernanalysis, 158 colorectal and 158 oesophagogastric cancer patients at the time of data collectionrnperiod were consecutively included. SPSS version 21 was used for the analysis. The validity andrnreliability were evaluated in terms of acceptability, internal consistency, face validity,rnconvergent, divergent, clinical validity and unidimensionality of the tools. rnResult: Among the participants 52.2% were male. The median age of the participants was 48rn(IQR =17.75). The alpha values ranged from 0.47- 0.91 and 0.39 - 0.7 for colorectal andrnoesophagogastric tools, respectively. Multi trait scale analysis showed that all itemsrncorrelations within their scales were greater than 0.4 except for blood and mucus in stool,rndysphagia, eating and odynophagia scales. The value of correlation coefficients between allrnitems and their own domain were higher than other domains except for eating, odynophagia,rndysphagia, anxiety, and blood and mucus in stool scales. The correlation between the corernquestionnaire and colorectal tool ranged from -0.46– 0.57. Similarly, oesophagogastric and therncore questionnaire correlation extended from -0.65-0.62. The tools also discriminated amongrnclinically distinct groups. rnConclusion: Even though the tools’ clinical validity was supported, the convergent andrndivergent validity of eating, odynophagia, dysphagia, anxiety, and blood and mucus in stoolrnscales were not supported. Thus, the finding suggested doing confirmatory factor analysis.

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