Ethiopia is predominantly dependent on rain-fed mixed farming with traditional technologies,rnand it is the backbone of the countryâ€™s economy, but the most vulnerable sector to climaternchange and variability. The objective of this study was to assess climate change adaptionrnresponse and its impact on household food security in Basona Werana Woreda Amhara region,rnEthiopia. From the cross-sectional survey of 138 farm households from Wayou Kebeles andrntime-series climate data from metrological satellite data was employed. The primary andrnsecondary data were analyzed by using both qualitative and quantitative methods of datarnanalysis. Both descriptive and inferential statistics were used to analyze farmersâ€™ food securityrnstatus and adaptation options to climate change and variability. To assess household foodrnsecurity status of the respondentâ€™s household food consumption score and household foodrninsecurity access scale was used, tobit model was used to examine climate change adaptationrnoption and ordered logistic regression was employed to examine the contribution of climaternchange adaptation on the food insecurity status of households. The result showed frequency ofrnextension service, training access, farm size, and gender of the household head, frequency ofrnflood and access for credit showed a significant impact for adaption. The ordered logisticrnregression model showed that household food security status were significantly influenced byrncultivated land procession, Crop failure, soil and water conservation participation, small scalernirrigation use, diversification of new crop varieties, diversification of sources of livelihood,rnagro-forestry, fertilizer application. Therefore Policies and implementation on climate changernadaption strategies should emphasized on a collaborated action climate smart approach tornreduce the impact of climate change on agricultural sector across the national level and localrnlevels to enhancing household food security.