Three main fish species cammanly utilized by cammercial gil/net fishery fi'am Lake Tana arernLabeabarbus species, C.gariepinus and 0. nilaticus. As fish canstitute an important part a/rnhuman diet, it is imperative to. examine the quality and sqrety aspects a/ fish that are a/rnparticular interest. Fish bady campasitian is affected by exagenaus and endogenaus /actars. Arnwide range a/ heavy metals are cantinuausly intraduced in to. the aquatiC environment mainlyrndue to. anthrapagenic pallutian and hence accumulated in fish tissue. As matter a/ qforementianed/rnacts, this study was aimed to. investigate the praximate campasitian a/ often used fishrn;pecies, and determined heavy metal (Cr, Cd and Pd) cancentratian a/ the common fish speciesrnand habituated water a/ Lake Tana. Six sites were systematically selected fi'am Lake Tana. Thernselectians a/ the sampling sites were based an their proximity to. expected IInthropugenicrnemissian saurces. A tatal 0./72 fish specimens were callected alang with six samples (replicatedrnthree time per site) water a/ Lake Tana in FebruCIIY 2014. At the spat aJ sample callectioll,rnmeasurments Jar temperature, pH, electrical candactivity, and tatal dissalved sal ids. Bath jishrnand water samples were transparted to. Faad Science and Nutritian labaratary under caal andrnaseptic canditians using ice bax. Samples were dried at 60 °C jor 72 hI'S, pulverized in a martaI',rnand stored in palyethylene bag until analysis for proximate compasitian and heavy /IIetalrnconcentratian. Analyses were made based main ~frects: lacatian, sex and ;p ecies. Praxill1i11erncampasitian was determined Jallawing the pracedure a/ AOAC while heavy metals were IIetrndigested and estimated using GFAAS. Data were analyzed using/actarial treatment arrangell1entrna/ ANOVA. There was significant variatian between sex, lacatian and species with regard tornnutritianal value. Generally, Jemale fish had higher nutritianal value as cal7lpared to theirrncaunter male. Praximate campasitian significantly varied between different sampling lacations.rn0. nilaticus had significantly highest levels aJpratein (18.82%) campared to. bath C. gariepililisrn(1 5.2%) and L.intermedius (15.44%) fish species. Hawever, L.intermedius had signijical1flvrnhighest Jat cantent (2.36%) and grass energy (83.1 Kcal11 00g) relative to. bath L. intermedius andrnC. gariepinus. Likewise there was significant variatian an heavy metal accumulatian be/llieenrndifferent sampling lacatian andfish species. The trend aJheavy metals accumulation were in thernorder aJ magnitude aJ Cr > Cd> Pd in all sampling lacatian and fish species. The heavy melalrncancentratian and physicachemical variables aJ Lake Tana were within the range 0/ thernrecammended limit aJ WHO (2008). Anthrapogenic pol/utian 0/ the lake seems to. pase no. II/reotrnoj heavy metal accumulatian regarding the studiedjish species. The heavy metal cantent af /hernstudied fish species remained in line 'with /aad safety and quality regulation 0/ WHO (1993)rnguidline Jar cansumptian. Hence, it was cancluded that the cansumptian aJ L. intermedius, C.rngariepinus, 0. nilaticus ji-am lake Tana are gaad saurces a/protein and ather nutrients and 1/10Prnnat lead to. health hazards induced by heavy metals.rnKey words: LakeTana. L.inlermedius, C. gariepinus, 0. nilaticlls · Proximate composition·rnHeavy metals· Physico-chemical· Bioaccllmlliatioll. Food safety