Human tuberculosis (TB) which is caused by Mycobacterium tuberculosis is the leading global healthrnchallenge. Regular surveys on the burden of this disease at a microenvironment level are vital torngenerate up-to-date information to effectively control TB in a locality. Thus, this study was designedrnto estimate the prevalence of pulmonary tuberculosis (PTB) and assess current intervention practicesrnin Ambagiorgis, northwest Ethiopia. The study (January-May 2016) was a descriptive surveyrninvolving both primary and secondary data sources collected from Ambagiorgis health center (AHC).rnTen-year (January 2006-December 2015) retrospective data containing PTB suspects and smearconfirmedrncases were extracted from the health center registration logbook. For the current crosssectionalrndata, PTB suspects visiting the health center between January-May 2016 were included in thernstudy. Pertinent information on socio-demography and participant knowledge, attitude and practicesrn(KAP) was secured through a questionnaire and interview. Some selected AHC personnel were alsornused to generate data on current TB control practices and related activities within the health center.rnData were organized and analyzed quantitatively using descriptive statistics, univariate andrnmultivariate logistic regression models. In the past ten years, 4218 PTB suspected patients werernregistered on TB laboratory logbook. Of these, 252 (5.97%) were smear-positive, 127(6.53%) malesrnand 125(5.2%) females. The highest PTB suspects were recorded in 2012 (16.2%) and the least inrn2006, (3.2%). The highest number of smear-positives was in 2007 (17.4%) and lowest in 2011 (2.5%).rnAll the health personnel (n=17) confirmed that the current control practice was adequate althoughrnthere was budget inadequacy. There were 110 males and 90 females of which 9 (8.9%) and 7 (7.8)rnwere PTB smear-positive, respectively, in the current cross-sectional survey. There was significantrndifference among study participants from rural and urban areas (p=0.023). There was also statisticalrnsignificant differences between knowledge of patients about transmission of PTB and infectionrnprevalence of PTB (p=0.027). Majority of the respondents had awareness about PTB and practiced thernrecommended TB preventive measures likely resulting in the observed lower prevalence for the studyrnarea. But further work is required to correct some misconceptions still circulating among certainrncommunity members about the public health importance of TB and maximize the choice of modernrndrugs. The control efforts must be further strengthened to sustainably control TB in the area.rnKeywords:, Mycobacterium tuberculosis, Amba-giorgis,