Infonnation pertaining to the etiologic agents responsible for ear infection are absent inrnEthiopia. Therefore, this study was initiated to identify the causative agents together withrntheir sensitivities to antimicrobials. Microbiological samples were collected from 389 earsrnof 355 patients attending the E. N. T. clinics of two Hospitals (Addis Ababa). Four hundredrnand twenty (98.4%) bacterial strains and 7 (1.6%) fungi were isolated. Gram-negativernbacteria were most frequently encountered. Of these 60.4% were members of the familyrnEnterobacteriaceae. Of all the isolates, Proteu spp. (25.5%), Pseudomonas aentginosarn(13.1%), Staphylococcus aureus (12.7%), and Klebsiella spp. (9%) were common. Allrnbacterial strains were tested for their susceptibility to antibiotics following a standardizedrnmethod. Ampicillin, tetracyclline, penicillin, and cephalothin were the least effectivernantimicrobials in their respective order. Pseudomonas aentginosa was the predominantlyrnresistant organism to several antibiotics (all strains were resistant to one or morernantibiotics, 93 % resistant to four or more antibiotics, and 71 % resistant to six or morernantibiotics). Strains of Proteus mirabilis were resistant to tetracyclline in 97% andrnStaphylococcus aureus was resistant to penicillin G in 82 %. This study has showen thernpolymicrobial etiology of ear infections with P. mirabilis being the dominating organism.rnGentamycin and carbenicillin were among the effective agents agaist most of the bacterial isolates.