Malaria constitutes one of the major health problems in Ethiopia. One of the reasonsrnattributed for the increase was the development of resistance of Plasmodium falciparumrnto antimalarial drugs. A continued search for other effective, safe and cheap plant-basedrnantimalarial agents thus becomes urgent in the face of these difficulties. The objective ofrnthe present study was therefore to evaluate in vivo antiplasmodial activities of successivernextracts of Clerodendrum myricoides and Dodonaea angustifolia leaves and possiblyrnisolate active ingredients. They were evaluated for their antimalarial activity in 4-dayrnsuppressive assays against Plasmodium berghei strain in Swiss albino mice. Thernconcentrated methanol extract of leaves of C. myricoides and D. angustifolia presentedrnrelatively high activities, which reduced the parasitemia by 76.66% and 80.89% at an oralrndose of 300mg/kg/day, 76.99% and 78.27% at an oral dose of 500mg/kg/dayrnrespectively. On the other hand, the chloroform/ethyl acetate (1:1) and chloroformrnextracts of these plants did not inhibit the parasitaemia significantly. Ethyl acetate extractrnobtained from successive extraction of methanol extract of D. angustifolia suppressedrnparasitaemia significantly (82.24% at 150mg/kg). Similarly the same dose of ethylrnacetate and residue (ethyl acetate insoluble) extract of C. myricoides methanol extractrnalso showed moderate inhibition activity with 61.30% and 69.31% mean suppressionrnrespectively. The TLC, Column chromatography and NMR spectrometer results of thernextracts of these plants indicated that they are rich in natural chemical constituents. Thernresults showed encouraging indications for further refined work on the use of these plantsrnas sources of antimalarial plants.rnKEY WORDS: Clerodendrum myricoides, Dodonaea angustifolia, malaria, medicinalrnplants, Plasmodium berghei, traditional medicine