Intestinal parasitic infections (IPIs) are still quite common in low-income countries includingrnEthiopia, particularly in children due to low-quality drinking water, poor personal andrnenvironmental sanitation. Periodic evaluation of the current status of IPIs in a locality is a prerequisiternto better control these health threats. Thus, the objective of this study was to assess the prevalencernand determinant factors of IPIs among school-age children in Mekaneselam, northwestrnEthiopia. The study was conducted at Mekaneselam health center and its design was crosssectionalrnand retrospective investigation. Stool samples collected in November 2015 - May 2016rnwere analyzed using the direct-wet method. Retrospective data recorded between Novemberrn2014 and May 2015 was also extracted from the health record system. Structured questionnairernwas used to gather data on environmental, socio-demographic and behavioral variables. Datarnanalysis was done using the chi-squared test. In the retrospective investigation, out of 314rnpatients examined 249(79.3%) had microscopy-confirmed IPIs. Ninety (28.7%) Entamoebarnhistolytica/dispar/moshkovskii, 84(26.8%) Giardia lamblia, 14(4.5%) hookworm and 61(19.4%)rnAscaris lumbricoides were detected. Totally 227 fresh stool samples were examined in the crosssectionalrnsurvey and 133(58.6%) were positive for IPIs. There were 51(22.5%) E.rnhistolytica/dispar/moshkovskii, 57(25.1%) G. lamblia, 15(6.6%) hookworm and 10(4.4%) A.rnlumbricoides cases. The results indicated that IPIs were common health problem among thernschool-age children. Source of drinking water and hand washing practice before meal werernsignificantly associated with positivity for IPIs (X2=0.166, p=0.809). Thus, there is a need forrnintensive and habitual health education for behavioral changes related to personal hygienernand mass treatment for effective control of IPIs in the study area.rnKeywords: Prevalence, Entamoeba histolytica/dispar/moshkovskii, Giardia lamblia, Ascarisrnlumbricoides, hookworm