The purpose of this study was to examine determinant factors contributing towards employeeâ€™s Turnover Intention in Ethiopian Federal Police Commission (EFPC). A sample of 394 was selected from five sectors of the Commission by using simple random sampling techniques. Human Resource Development Sector, Police University College, Health Sector, Crime Prevention Sector and Crime Investigation Sectors are the directorates the police officers were selected from. Out of the 394 questionnaires distributed 387 (96.0%) questionnaires were collected. All the data gathered from the respondents were analyzed using SPSS descriptively and inferentially. The descriptive statistics result indicated a moderate level of agreement with the items that measure all variables of the study. The results of the correlation analysis indicated moderate association of four (Salary, Employee Promotion, Employee Benefit, and Working Environment) and substantive associations of two independent variables (Supervision and Job Satisfaction). The model summary part of the regression analysis indicated that 42.5% of the variation in turnover intention in EFPC can be explained by the six independent variables. The ANOVA analysis also explained the existence of significant relationship between the independent variables and the dependent variable. However, the individual contribution of each of the independent variable to the dependent variable was found out to be non-significant. As a result, none of the hypothesis was supported. To improve the situation it is recommended that the Commission should examine its current practices and should take progressive steps on salary, promotion, benefits, working environment, supervision, and job satisfaction of the employees to minimize turnover intention to its lowest degree