The aim of the study is to identify the effect of HRM practices on job satisfaction at Hibret Bank S.C. The study used a quantitative approach by using survey method to examine the relationship between independent (work environment, recruitment, learning and development, employee recognition, promotion, job security, performance management, and compensation) and dependent (job satisfaction) variables. The study used a descriptive and explanatory design. The quantitative data gathered from questionnaires and qualitative data gathered from different documents. The target population involved in this study are Managerial and clerical employees of Addis Ababa located branches and head office. Simple random sampling techniques are used to distribute the questioner for a sample of 357 employees and out of them 262 respondents returned the questionnaires. This study has applied descriptive statistical tools to compute the data in terms of mean & standard deviation and also inferential statistics to generate correlation and multiple regression analysis. The result shows that the level of job satisfaction at Hibret Bank on compensation, PMS, Promotion, Job Security and employee recognition practice is low level and on the implementation of Learning & Development, Working Environment, and Recruitment is relatively high. According to the correlation and regression analysis result there are a positive relationship between the HRM practices and job satisfaction in Hibret Bank. Finally, the study recommended that Hibret Bank should develop and implement a strategic HRM practice to enhance employee job satisfaction