Background; in this era of COVID-19 epidemic health care workers are at increased risk ofrncontracting the disease. The WHO estimates that around 20% of HCW have already acquired therninfection in the world worst affected areas. It is a paramount important to prevent spread of infectionrnamong the HCWs as they can be a source of community transmission. There are some evidencesrnshowing there is a gap in knowledge, attitude and practice of personal protective equipment usernamong the health care workers. rnObjective: To assess knowledge, attitude and practice of PPE among HCWs that are currentlyrnworking in Tikur Anbessa Specialized hospital and Eka Kotebe general hospital, Addis Ababa,rnEthiopia. rnMethodology: This cross-sectional, descriptive study was conducted on HCWs of TASH and EKGHrnin the month of October 2020. Participants were selected using convenient sampling method and 45rnitemed, web-based, self-administered questionnaires were used for data collection via internet access.rnData analysis was done using SPSS version 26. Socio-demographic and important informationrnassessing KAP were collected. rnResult: A total of 277 HCWs responded to the questionnaire from both centers. The mean age wasrn30.77Â±5.78 years. Among them majority was male (n=158, 57%) and majority were from TASH 261rn(94.2%). Medical doctors constituted 73.2% (n=203) followed by nurses (n=70, 25.3%). On average,rn38.6% had 8hours of work per day. Among the responders, 18.8% (n=51) uses informal ways torngather information and 19.1% (n=53) of HCWs tested positive for COVID-19. Knowledge, attitudernand practices regarding PPE use among these HCWs were 73.9%, 40.3% and 57.7% respectively. rnConclusion and Recommendation: This survey shows that there is poor attitude and practice of PPErnespecially N95 use among HCWs. Institution based training and inclusive updates needs to bernimplemented.