Background: Cirrhosis is the leading cause of liver-related death globally with the highest agernstandardized death rates recorded in low income countries in the Sub-Saharan Africa region.rnStudies that assess the short and long term outcomes of patients with chronic liver diseases inrngeneral and decompensated cirrhosis, in particular, are limited in Ethiopia. rnObjectives: This study was conducted to assess the short term outcomes of patients withrndecompensated cirrhosis at Tikur Anbessa Specialized Hospital (TASH) within 06 months of theirrnindex hospital visit/ admission, and to explore the prevalence and factors associated with poorrnoutcome among these patient groups. It also assessed the demographic and clinical characteristicsrnas well as the commonest etiologic causes of cirrhosis among the study participants. rnMethods: A single center, 1year retrospective cohort study was conducted including data fromrnmedical records of patients with decompensated cirrhosis who were admitted at the emergencyrndepartment (ED), intensive care unit (ICU), or medical wards, or were seen as an outpatient at thernGastroenterology (GI) clinic at TASH from March 2020 to March 2021. Chi-square statistics andrnbinary logistic regression were used to examine the presence and strength of association betweenrncategorical variables, and the Cox proportional hazard model was used to test the probability ofrnoccurrence of poor outcome among the study participants. The statistical significance was set atrnP< 0.05. rnResults: Among 110 participants in this study 82(74.5%) were male. The mean age (Â± SD) of thernparticipants was 40.35 (Â± 13.5) years and the median duration of known chronic liver disease wasrn20.5months (IQR 33). Chronic hepatitis B infection (46.36%) was the commonest identifiedrnetiology of cirrhosis followed by alcohol related cirrhosis and cryptogenic cirrhosis in 24.55%rn20.9% participants respectively. Sixty one hospital admissions were documented during the studyrnperiod, with 49(44.5%) participants having been admitted at index hospital visit. Upper GIrnbleeding, hepatic encephalopathy, and hepatocellular carcinoma were the most common reasonsrnfor hospitalization at all time points in the study. A total of 16(14.54%) participants died in thernhospital during the study period. Chronic HBV infection was found to contribute significantly tornoverall poor outcomes [AOR=4.4; 95%CI: 1.15-16.93]. A statistically significant association wasrnfound between age above 40years and the development of upper GI bleeding after adjustment forrnother variables, but not with other complications of portal hypertension [AOR=2.8; 95%CI: 0.765.44].rnrnHowever, sex, other etiologies of cirrhosis, Child Pugh score at index hospital visit/rnadmission and renal function were not found to be associated with poor outcome measures duringrnthe study period, (p>0.05). rnConclusion: Chronic HBV infection was the commonest etiology and a strong predictor of overallrnpoor outcome, whereas age above 40 years was a significant contributor to the development ofrnupper GI bleeding. Hepatic encephalopathy and upper GI bleeding were predictors ofrnhospitalization.